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Description
TFEB Recombinant Rabbit mAb (SDT-2411-7)Product Specification Host Rabbit Antigen TFEB Synonyms Transcription factor EB; Class E basic helix loop helix protein 35 (bHLHe35); BHLHE35 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Lysosome Accession P19484 Clone Number SDT 2411 7 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample Raji, Ramos, RAW264. 7, rat heart Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | TFEB |
| Synonyms | Transcription factor EB; Class E basic helix-loop-helix protein 35 (bHLHe35); BHLHE35 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Lysosome |
| Accession | P19484 |
| Clone Number | SDT-2411-7 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Raji, Ramos, RAW264.7, rat heart |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:250 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms |
Background
TFEB protein, which stands for Transcription Factor EB, is a crucial regulator of lysosomal biogenesis and autophagy. It is a member of the MiT family of transcription factors. When TFEB is activated, it translocates to the nucleus and binds to the promoters of various genes related to lysosomal and autophagy functions, thereby promoting the expression of these genes. This process helps cells to enhance their ability to degrade and recycle cellular components, which is essential for maintaining cellular homeostasis, especially under conditions of cellular stress such as nutrient deprivation or the presence of damaged organelles. Abnormal regulation of TFEB has been implicated in several diseases, including neurodegenerative diseases and lysosomal storage disorders, making it a potential therapeutic target.
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