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Description
TMEM106B Recombinant Rabbit mAb (S-2362-33)Product Specification Host Rabbit Antigen TMEM106B Synonyms Transmembrane protein 106B Immunogen Recombinant Protein Location Lysosome, Endosome, Cell membrane Accession Q9NUM4 Clone Number S 2362 33 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample PANC 1, HeLa, A549, HepG2, Jurkat, NIH 3T3, mouse brain, PC 12, rat brain, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | TMEM106B |
| Synonyms | Transmembrane protein 106B |
| Immunogen | Recombinant Protein |
| Location | Lysosome, Endosome, Cell membrane |
| Accession | Q9NUM4 |
| Clone Number | S-2362-33 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | PANC-1, HeLa, A549, HepG2, Jurkat, NIH/3T3, mouse brain, PC-12, rat brain, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IP | 1:500 | Hu |
| IHC-P | 1:100-1:500 | Hu, Ms, Rt |
Background
TMEM106B is a 274-amino-acid type II transmembrane protein embedded in late endosome and lysosome membranes, most highly expressed in central nervous system neurons and oligodendrocytes, where it critically influences lysosomal morphology, trafficking, and clearance of misfolded proteins; genetic variants—especially a threonine-to-serine polymorphism at residue 185—modulate its expression and stability and constitute major risk factors for frontotemporal lobar degeneration with TDP-43 pathology and other neurodegenerative disorders, while its C-terminal luminal domain can be proteolytically released by lysosomal cysteine proteases to form amyloid fibrils that accumulate not only in diseased but also in aged cognitively normal brains, thereby linking lysosomal dysfunction, myelin lipid dysregulation, and protein aggregation to neurodegeneration.
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